Pediatric inflammatory syndrome temporally related to covid-19

 

New research from France may help better characterize multisystem inflammatory syndrome in children associated with COVID-19. The analysis in The BMJ included 21 children admitted with features of Kawasaki disease between April 27 and March 11. For those who’d recently experienced viral symptoms, the median time from those symptoms to onset of Kawasaki-like illness was 45 days. For those with contact with a potential COVID-19 patient, the median time between that exposure and Kawasaki onset was shorter — 36 days. Some 90% of the children had positive PCR or serology tests for SARS-CoV-2. The median age at presentation was roughly 8 years, and 57% of the children were of African or Caribbean descent. Some 57% presented with Kawasaki shock and 76% with myocarditis. Over 80% were admitted to the ICU. All patients had gastrointestinal symptoms early in the illness, as well as leukocytosis and increased inflammatory markers. All received intravenous immunoglobulin, and half also received corticosteroids. All recovered and were discharged.

Multisystem inflammatory syndrome findings in The BMJ 

The BMJ editorial